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All of these activities directed at the T cell immunesystem have wide-ranging effects on the ability of the T cells in the system to maintainimmunological homeostasis within the body.

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The effects oflong-term exposure are characterized by continuous hyper-plasia and low-grade chronic inflammation with exudativecells, as well as synthesis of collagen in the matrix. (1999) WHO Infection Control Guidelines for TransmissibleSpongiform Encephalopathies: Report of a WHO consultation Geneva,Switzerland, 23-26 March 1999

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